The Nucleus: Volume 1: Nuclei and Subnuclear Components
Publisher: Humana Press | English | ISBN: 1588299775 | 350 pages | 2008 | PDF | 4 Mb
Description: Although our understanding of the structure and activities of the cell nucleus and of the nanomachines which it contains is increasing rapidly, much remains to be learned. The application and continuing development of the new, powerful biochemical and biophysical methodologies described here are essential in this quest. In The Nucleus, researchers from more than forty leading international laboratories describe state-of-the-art methods for isolating nuclei and their components and for studying their structure and activities, including some pathology-associated features. Volume I: Nuclei and Subnuclear Structures presents an overview of features of the intranuclear environment, followed by the most recent procedures for isolating nuclei from a wide range of cell types including muscle cells, yeast, oocytes, cells with polytene nuclei, Arabidopsis, trypanosomes, and dinoflagellates. The latest methods are described for isolating and working with nucleoli, constitutive heterochromatin, pathology-associated inclusions, and chromatin and for examining glycosylation, sumoylation, and ADP-ribosylation of nuclear proteins. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain lists of necessary materials and reagents, readily reproducible protocols, and tips for troubleshooting and avoiding known pitfalls.
The Nucleus, Volume I: Nuclei and Subnuclear Structures is an essential reference for scientists who are working on our rapidly growing understanding of the cell nucleus and its activities.
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Eukaryotic Membranes and Cytoskeleton: Origins and Evolution
Publisher: Springer | Language: English | ISBN:0387740201 | 162 pages | Data: 2007 | PDF | 15 Mb
Description: Eukaryotic Membranes and Cytoskeleton: Origins and Evolution discusses the evolutionary origin and diversification of eukaryotic endomembranes and cytoskeleton from a cell biological and comparative genomic perspective. Many of the chapters present original research data from comparative genomic surveys. The presence/absence of gene families with central roles in endomembrane and cytoskeleton dynamics in a variety of eukaryotic taxa and an understanding of eukaryote phylogeny allow us to accurately reconstruct the cellular machineries present in the last common ancestor of eukaryotes. Such a reconstruction is fundamental if we are to understand eukaryotic diversification since this is the ancestral cell from which all diversity arose. Comparative genomics can likewise tell us which lineages expanded or reduced certain gene families and the associated cellular machineries.
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Meat Biotechnology
Publisher: Springer | Language: English | ISBN:038779381X | 516 pages | Data: 2007 | PDF | 5 Mb
Description: Meat and meat products constitute one of the most important foods in western societies. However, the area of meat biotechnology is not as comprehensively covered as other areas of food biotechnology. Missing from this area are the recent developments for better sensory and nutritional quality as well as improved safety.
The main goal of this book is to provide the reader with the recent developments in biotechnology and their applications in the meat processing chain. To achieve this goal, the book is divided into four parts. The first part deals with the use of modern biotechnology applied to farm animals. The second part focuses on the recent biotechnological developments in starter cultures for better meat fermentation. The third part discusses current approaches to improve the quality and nutritional properties of meats. The final part presents the latest advances in protection against foodborne pathogens, and other recent trends in the field. Written by distinguished international contributors, this book brings together the advances in such varied and different biotechnological topics.
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Targeted Radionuclide Tumor Therapy: Biological Aspects
Publisher: Springer | Language: English | ISBN:1402086954 | 402 pages | Data: 2007 | PDF | 5 Mb
Description: The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. The expanding array of new targeting molecules (recombinant antibodies or peptides) may increase the therapeutic efficacy. The title of this book "Targeted Radionuclide Tumor Therapy – Biological aspects" was selected to reinforce the concept that a major focus was devoted to understanding the biological effects of targeting and radiation. Furthermore, our rapidly expanding knowledge of low dose-rate effects, different types of cell death, autosensitization and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.
The development of targeted therapy is a true multidisciplinary enterprise involving physician scientists from the fields of nuclear medicine, radiation therapy, diagnostic radiology, surgery, gynaecology, pathology and medical oncology/haematology. It also involves many preclinical scientists working with experimental animal models, immunochemistry, recombinant antibody technologies, radiochemistry, radiation physics and basic cell biology.
It is the ambition of the editors to enable deeper insights in the process of improving targeted therapy. We believe that the time now has come when targeted therapy can soon be added to standard oncology treatment regimens.
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Handbook of Secondary Fungal Metabolites
Publisher:Academic Press | Language: English | ISBN:0121794601 | 2498 pages | Data: 2003 | PDF | 1 Mb
Description: This three-volume set is a desirable reference for a wide range of specialists who study secondary fungal metabolites ranging from pharmaceutical house researchers, agricultural researchers, those involved in food and feed control regulation, and veterinary researchers. It discusses in depth the molecular formula of, the molecular weights of, and fungal/plant source indexes of secondary fungal metabolites.
* Includes all major groups of secondary fungal metabolites
* Covers various methods used to isolate and purify metabolites are present
* Each metabolite is supported by appropriate references
* Secondary metabolite molecular formula, molecular weights and fungal/plant source indexes are included
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The original link would be as follows:
48,1 MB, rared pdf file, all three volumes
http://rapidshare.com/files/130674208/COLE.rar
Wiley Encyclopedia of Clinical Trials
Publisher:Wiley-Interscience | Language: English | ISBN:0471352039 | 2402 pages | Data: 2008 | PDF | 1 Mb
Description: This monumental reference on all facets of clinical trials is important reading given its comprehensive coverage and emphasis on clearly stated and defined concepts, methodologies, and applications. Including more than 1,200 entries, from 600 of the world's leading experts in the field, from academic to corporate settings, Encyclopedia of Clinical Trials is a world-class and one-of-a-kind compendia of basic concepts, methodologies, and applications in clinical trials. The book's topical range includes: overview and basic statistical concepts; concepts of design and analysis of clinical trials; and methodologies and issues for clinical data analysis.
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