Design of Caspase Inhibitors as Potential Clinical Agents
Publisher: CRC | Language: English | ISBN:1420045407 | 327 pages | Data: 2008 | PDF | 8 Mb
Description: Caspases represent one of the most specific protease families described to date. As caspase family members are involved in pro-inflammatory responses, inhibition of caspase activity represents a novel yet core approach to disease treatment. Design of Caspase Inhibitors as Potential Clinical Agents discusses the role of cysteine aspartyl proteases (caspases) in inducing cell death. It reviews recent efforts to develop small molecular inhibitors that are capable of modulating caspase activity. The text also examines the difficulties encountered in transitioning small molecular inhibitors from the lab to clinical use, and discusses how these challenges can best be overcome to allow continued progress.
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Gene and Cell Therapy - Therapeutic Mechanisms and Strategies
Publisher: CRC | Language: English | ISBN:084938768X | 1160 pages | Data: 2008 | PDF | 30 Mb
Description: This latest edition of Gene and Cell Therapy provides comprehensive coverage of all aspects of the tools and state-of-the-art technologies that are currently available in this field. Written by international leaders, this third edition features 12 additional chapters that address such new topics as gene and cell therapies for diabetes and cardiovascular disease, relevant nanotechnologies, siRNA therapeutics, dendrimers, clinical trials, human embryonic stem cell research, tissue engineering, and novel polymers. All chapters in the text have been substantially updated and revised to reflect the latest information available in the field.
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Ernst-Detlef Schulze, Erwin Beck, Klaus Muller-Hohenstein"Plant Ecology"
Published by Springer | Publication date May 24, 2005 | ISBN : 354020833X | PDF Format, 693 pages | 31 MB
Overview :
This textbook covers Plant Ecology from the molecular to the global level.
It covers the following areas in unprecedented breadth and depth:
- Molecular ecophysiology (stress physiology: light, temperature, oxygen deficiency, drought, salt, heavy metals, xenobiotica and biotic stress factors)
- Autecology (whole plant ecology: thermal balance, water, nutrient, carbon relations)
- Ecosystem ecology (plants as part of ecosystems, element cycles, biodiversity)
- Synecology (development of vegetation in time and space, interactions between vegetation and the abiotic and biotic environment)
- Global aspects of plant ecology (global change, global biogeochemical cycles, land use, international conventions, socio-economic interactions)
The book is carefully structured and well written: complex issues are elegantly presented and easily understandable. It contains more than 500 photographs and drawings, mostly in colour, illustrating the fascinating subject.
The book is primarily aimed at graduate students of biology but will also be of interest to post-graduate students and researchers in botany, geosciences and landscape ecology. Further, it provides a sound basis for those dealing with agriculture, forestry, land use, and landscape management.
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James A. Duke “Duke's Handbook of Medicinal Plants of Latin America"
CRC | 2008-10-24 | ISBN: 1420043161 | 832 pages | PDF | 8,6 MB
A Comprehensive Guide Addressing Safety, Efficacy, and Suitability
About a quarter of all the medicines we use come from rainforest plants and more than 1,400 varieties of tropical plants are being investigated as potential cures for cancer. Curare comes from a tropical vine and quinine from the cinchona tree. A comprehensive guide to safety, efficacy, and suitability, Duke’s Handbook of Medicinal Plants of Latin America responds to continuing interest in medicinal plants and the potential remedies they contain.
Determine Which Species Can Be Used for Specific Targets
The author of Green Pharmacy Herbal Handbook and CRC Handbook of Medicinal Herbs, James A. Duke covers roughly 500 of the more important Native Latin American medicinal plants in a highly organized format. After a brief introduction, each entry contains scientific and colloquial names, synonyms, reference to illustrations, notes, biological activities, medicinal indications, dosages, potential hazards, extracts, and references. This format supplies a starting point for determining which species can be used for specific targets.
Better Data Helps You Focus Your Search
Year-round moderate temperatures, abundant rainfall, and rich soils make tropical Latin America home to nearly 100,000 of the world’s 300,000 known species of plants, and therefore home to untold numbers of potential cures. Focusing on 500 of the most well-known and well-studied plants, this book helps you focus your search for ammunition against constantly evolving pathogens and newly emerging diseases.
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Shein-Chung Chow, Jen-pei Liu “Design and Analysis of Bioavailability and Bioequivalence Studies, Third Edition"
Chapman & Hall/CRC | 2008-10-15 | ISBN: 1584886684 | 760 pages | PDF | 3,5 MB
Taking into account the regulatory and scientific developments that have occurred since the second edition, Design and Analysis of Bioavailability and Bioequivalence Studies, Third Edition provides a complete presentation of the latest progress of activities and results in bioavailability and bioequivalence on regulatory requirements, scientific and practical issues, and statistical methodology.
New to the Third Edition
• Four new chapters that present a thorough account of novel developments in the field
• New and updated sections that reflect recent advances in the statistical methodology in the design and analysis of bioavailability and bioequivalence studies
• Reorganization of the material into five parts, making it easier to access related information together
• Over 100 new references from the literature
Like its bestselling predecessors, this edition covers all of the statistical problems that may occur in the various stages of design and data analysis. Keeping the mathematics and statistics at a fundamental level, it continues to focus on practical concepts rather than technical details.
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Studies in Natural Products Chemistry: Bioactive Natural Products Part (O)
Elsevier Science | ISBN: 0444531815 | 2008-09-12 | PDF | 966 pages | 72.12 Mb
This volume presents frontier reviews on recent developments on bioactive natural products in cutting-edge areas by eminent experts in their respective fields. It is an essential addition to this important series on Natural Products Chemistry, generally acknowledged to be the leading series on this topic. The first seven reviews cover recent developments in the field of bioactive marine natural products. Additional coverage includes Novel Domino reactions; medicinal plants and phytochemicals; recent developments in bioactive natural peptides; the chemistry and pharmacology of natural cyclic lipopeptides; and the biological activities of Salvia .
The text includes a comprehensive review of biologically active compounds of semi-metals such as boron, silicon, arsenic, selenium and tellurium.
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Stephen Garrard Post “Encyclopedia of Bioethics 5 Volume Set"
MacMillan Reference | 2003 | ISBN: 9780028657745 | 3062 pages | PDF | 14,2 MB
*Starred Review* When the first edition of the Encyclopedia of Bioethics appeared in 1978, the discipline was new and relatively undefined. The second edition, in 1995, kept pace with the rapid changes in the field. Continuing advances in biological and medical research have created the need for yet another edition. Bioethics has become a recognized field, "the interdisciplinary examination of the moral and ethical dimensions of human conduct in the areas of life sciences and health care." With such a broad, rapidly changing subject area to cover, editor Post (Department of Bioethics, School of Medicine, Case Western Reserve University) has assembled an international group of more than 500 scholars from 18 major disciplines-- behavioral sciences, medicine, economics, ecology, philosophy, religion, and so on--to write 448 articles. The third edition has 120 new articles, among them Artificial nutrition and hydration, Bioterrorism, Cloning, Cybernetics, Dementia, Managed care, and Nanotechnology. Some 200 articles have been extensively revised, and 100 additional articles have new bibliographies. The alphabetical entries address a wide range of topics that raise difficult and important questions. Abortion, genetic screening, female genital mutilation, the right to die, health issues of immigration, and corporate responsibility are but a few. The contributors discuss the issues from many points of view. The abortion article includes sections covering medical perspectives, contemporary ethical and legal aspects, and Jewish, Catholic, Protestant, and Islamic religious perspectives. There are also articles about bioethics in Buddhism, eugenics, health policy, women as health-care professionals, whistle-blowing in health care, and veterinary ethics. All of the articles are signed, and all have bibliographies. Ample cross-references help readers find related useful material. A list of all the articles and a topical outline appear in volume 1. A series of appendixes offers codes, oaths, and directives related to bioethics; additional resources; key legal cases; and an annotated bibliography of literary works that have a medical component. A detailed index helps users find material that may be scattered over numerous entries, such as information about surrogate motherhood.
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Robert C. Elston, William Johnson “Basic Biostatistics for Geneticists and Epidemiologists: A Practical Approach"
Wiley | 2008-12-31 | ISBN: 0470024895 | 384 pages | PDF | 1,53 MB
Anyone who attempts to read genetics or epidemiology research literature needs to understand the essentials of biostatistics. This book, a revised new edition of the successful Essentials of Biostatistics has been written to provide such an understanding to those who have little or no statistical background and who need to keep abreast of new findings in this fast moving field. Unlike many other elementary books on biostatistics, the main focus of this book is to explain basic concepts needed to understand statistical procedures.
This Book:
Surveys basic statistical methods used in the genetics and epidemiology literature, including maximum likelihood and least squares.
Introduces methods, such as permutation testing and bootstrapping, that are becoming more widely used in both genetic and epidemiological research.
Is illustrated throughout with simple examples to clarify the statistical methodology.
Explains Bayes’ theorem pictorially.
Features exercises, with answers to alternate questions, enabling use as a course text.
Written at an elementary mathematical level so that readers with high school mathematics will find the content accessible. Graduate students studying genetic epidemiology, researchers and practitioners from genetics, epidemiology, biology, medical research and statistics will find this an invaluable introduction to statistics.
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Beyond Biomechanics
Publisher: CRC | Pages: 336 | 1996-02-08 | ISBN: 0748403213 | PDF | 3 MB
Product Description:
There is now widespread recognition that psychosocial factors play a key role in the aetiology, perpetuation, management and prevention of cumulative trauma disorders CTDs. This text addresses the strength, direction and importance of links between psychosocial factors and CTDs.; The book's contributors examine critically current research data, identify potential link mechanisms, and recommend measures for control and prevention. Topics covered include socio-organizational psychology, medical anthropology, occupational medicine, rehabilitation, orthopaedics, job stress and ergonomic interventions. The book aims to demystify the concept of the "psychosocial", so as to promote and assure effective prevention in the workplace.
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Joel L. Sussman “Structural Proteomics And Its Impact On The Life Sciences"
World Scientific Publishing Company | 2008-05-06 | ISBN: 9812772049 | 600 pages | PDF | 45,5 MB
The role played by structural proteomics in the first decade of the 21st century is equivalent to that played by the Human Genome Project in the last decade of the 20th century. The development of high-throughput technologies that permit the solution of hundreds of 3D structures of individual proteins, protein protein complexes and protein drug complexes, just by one laboratory in a single year, will provide a knowledge base which will change the face of structural biology. This will have an immediate influence on medicinal chemistry and molecular pharmacology, as well as an increasing impact on such disciplines as neurobiology, developmental biology, immunology and molecular medicine.
This book presents a state-of-the-art overview of the structural proteomics field, ranging from policy issues related to funding and goals, through the high-throughput procedures for protein production, to the solution of the structures of proteins and higher-order entities, via a multidisciplinary approach involving molecular biology, X-ray crystallography, NMR and electron microscopy, as well as bioinformatics analysis. This is the first book to provide such a comprehensive coverage of a rapidly evolving field.
Contents: The Importance of Target Selection Strategies in Structural Biology (E E Abola & R C Stevens); The Impact of Structural Proteomics on Macromolecular Structure Databases (J D Watson & J M Thornton); The Impact of 3D Structures on a Protein Knowledgebase: From Proteins to Systems (U Hinz & A Bairoch); Bioinformatics of Protein Function (A M Lesk et al.); Comparative Modeling in Structural Genomics (J Moult); The Contribution of Structural Proteomics to Understanding the Function of Hypothetical Proteins (M D Suits et al.); Intrinsically Disordered Proteins (P Tompa); Metalloproteins: Structure, Conservation and Prediction of Metal Binding Sites (M Edelman et al.); The Impact of Protein Expression Methodologies on Structural Proteomics (A Chesneau et al.); Protein Complexes Assembly by Multi-Expression in Bacterial and Eukaryotic Hosts (C Romier); The Impact of Structural Proteomics on the Prediction of Protein-Protein Interactions (C Kiel & L Serrano); Cryo-Electron Microscopy in the Era of Structural Proteomics (A C Steven & D M Belnap); On NMR-based Structural Proteomics (T Szyperski); Structural Proteomics in Relation to Signaling Pathways (F Bedez et al.); The Impact of Structural Proteomics and Drug Design (Y-P Pang); Structural Proteomics of Emerging Viruses: The Example of SARS-CoV and Other Coronaviruses (R Hilgenfeld et al.); High-throughput Technologies for Structural Biology: The Protein Structure Initiative Perspective (A Joachimiak); European Structural Proteomics A Perspective (S Daenke et al.); Structural Genomics and Structural Proteomics: A Global Perspective (L Banci et al.); Policies in Structural Genomics/Structural Proteomics (J Norvell & J Berg).
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John E. Sheehy “Charting New Pathways To C4 Rice"
World Scientific Publishing Company | 2008-03-28 | ISBN: 9812709517 | 436 pages | PDF | 20,1 MB
Feeding Asia in the 21st century will require a second Green Revolution. However, unlike in the first generation, future yield increases will have to be grown using less water and nitrogen in a world of unfavorable climate change -- this can only be done by increasing the efficiency of the photosynthetic system, i.e. developing a C4 rice plant. If and when achieved, it would be the first nonevolutionary example of reconstructing the primary metabolism of a plant. The impact of such a scientific achievement would be undeniable, but it requires either a superb feat of genetic engineering or forced evolution.
This book describes the alternative ways of achieving C4 photosynthesis in rice. Featuring contributions from leading experts, case studies are used to present views on how C4 rice might be constructed and applied, along with the socioeconomic implications that it entails. Ultimately, readers will be better informed about this highly relevant and timely topic of improving rice yield in a global environment grappling with unpredictable climate change.
Contents: Setting the Scene; C4 Rice from Theory to Practice; Single-Cell C4 Systems; The Background and How C4 Rice can be Delivered; Setting Up the Consortium.
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Hiroshi Wada “Biomechanics at Micro- And Nanoscale Levels Volume II"
World Scientific Publishing Company | 2006-04-18 | ISBN: 9812567461 | 176 pages | PDF | 13,4 MB
This book is essential reading for those interested in understanding current research trends in biomechanics at micro- and nanoscale levels. It details the research carried out to date in this field by fourteen prominent researchers as part of a four-year government supported project which commenced in 2003. The coverage includes four broad areas: cell mechanics, cell response to mechanical stimulation, tissue engineering, and computational biomechanics.
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